dating now drama - What invalidating breast cancer gene patents implies

In one aspect, the fusion protein comprising the following protein or fragments: i) the wild-type K-ras, N-ras or the amino acid of the number 12 position of the glycine is substituted with a cysteine ​​in the No.

12 position in relation to the H-ras protein containing mutated Ras protein or a fragment thereof; ii) wild-type K-ras, N-ras or H-ras mutation in relation to the protein containing the amino acid glutamine is the time of the time position 61 substituted with arginine 61 located Ras protein or a fragment thereof; iii) wild type K-ras, N-ras or H-ras mutation in relation to the protein containing the amino acid number 12 of a glycine in position number 12 is substituted with aspartic acid position Ras protein or a fragment thereof; iv) the wild-type K-ras, N-ras or H-ras mutation in relation to the protein containing the amino acid number 12 of a glycine in position number 12 is substituted with valine position Ras protein or a fragment thereof; v) the wild-type K-ras, N-ras or H-ras mutation in relation to the protein containing the amino acid number 12 of a glycine in position number 12 is substituted with arginine position Ras protein or a fragment thereof; vi) the wild-type K-ras, N-ras or H-ras mutation in which the glutamic acid in relation to the protein containing the amino acid at position 76 of the 76-position is substituted with glycine Ras protein or a fragment thereof.

Despite proposed a variety of innovative methods for the prevention and treatment of cancer, many cancer they can still cause high mortality rates, relatively difficult to treat, or not respond to traditional therapies.

what invalidating breast cancer gene patents implies-41

Another embodiment of the present invention have a cancer in an animal or in the risk of cancer caused, to a method for preventing or treating cancer which comprises administering an above-described any vaccine.

Another embodiment of the present invention have a cancer, or cancer in the at risk animal occurs, let the above-described random aptamer, the above-described random si RNA, Lai any of the above techniques of, or the above-described random It relates to a method of preventing or treating cancer which comprises administering an antisense nucleic acid molecule.본 발명의 또다른 구체예는암을 가지고 있거나 암이 발생할 위험이 있는 동물에서, 야생형 아미노산 서열과 관련하여 적어도 76번 위치의 돌연변이에 의해 야생형 K-ras, N-ras 또는 H-ras 아미노산 서열과는 구별되는 아미노산 서열을 포함하는 돌연변이 Ras 단백질의 발현을 저해하는 화합물을 투여하는 것을 포함하는 암의 예방 또는 치료 방법에 관한 것이다.

In one aspect, the fusion protein comprising the following protein or fragments: i) the wild-type K-ras, N-ras or the amino acid of the number 12 position of the glycine is replaced by arginine, the number 12 position with respect to the H-ras protein containing mutated Ras protein or a fragment thereof; ii) wild-type K-ras, N-ras or H-ras mutation in which the glutamic acid in relation to the protein containing the amino acid at position 76 of the 61-position is substituted with glycine Ras protein or a fragment thereof.본 발명의 또다른 구체예는 상기 기술된 핵산 분자 중 임의의 핵산 분자에 의해 전사되는 RNA, 또는 상기 기술된 돌연변이 Ras 단백질 중 임의의 단백질, 특히, 야생형 아미노산 서열 대비 76번 위치에서 적어도 하나의 돌연변이에 의해 야생형 K-ras, N-ras 또는 H-ras 아미노산 서열과 구별되는 아미노산 서열을 포함하는 돌연변이 Ras 단백질을 코딩하는 ras 유전자에 의해 전사되는 RNA의 선택적인 절단을 촉매하는 si RNA 분자에 관한 것이다.

Another embodiment of the present invention is at least one mutation in any of the protein, in particular, the wild-type amino acid sequence compared to 76-position of the mutated Ras protein, RNA, or the technology to be transferred by any of the nucleic acid molecule of the above-described nucleic acid molecule the invention relates to the wild-type K-ras, N-ras or H-ras for the selective cleavage of the RNA transcribed by the ras gene encoding the mutated Ras protein comprising an amino acid sequence that is distinct from the amino acid sequence catalyst si RNA molecule.본 발명의 또다른 구체예는 상기 기술된 핵산 분자 중 임의의 핵산 분자, 또는 상기 기술된 돌연변이 Ras 단백질 중 임의의 단백질, 특히 야생형 아미노산 서열과 관련하여 76번 위치의 적어도 하나의 돌연변이에 의해 야생형 K-ras, N-ras 또는 H-ras 아미노산 서열과는 구별되는 아미노산 서열을 포함하는 돌연변이 Ras 단백질을 코딩하는 ras 유전자의 불활성화를 선택적으로 촉매하는 라이보자임에 관한 것이다.

In one aspect, the amino acid sequence is the SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: for the glutamic acid of No.

76 position of the 13 non-SEQ ID NO: by substitution of the glutamic acid amino acid 3, any one of SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: 13 and one is differentiated.

Another embodiment of the invention relates to the use for the preparation of for preventing or treating cancer of the above-described any nucleic acid molecule described above or any protein or peptide composition.

Another embodiment of the present invention is of a medicament for preventing or treating cancer of said any of the aptamer, the techniques described any si RNA, let Lai any of the above techniques of, or the above-described random antisense nucleic acid molecule It relates to the use for the manufacture.

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414 Comments

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